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Adjective: enervating  e-nu(r)-vey-ting
  1. Causing debilitation
    "These graceful regrets are powerless, and on the whole they are very enervating"
    - debilitative, enfeebling, weakening
Verb: enervate  'e-nu(r)`veyt
  1. Weaken mentally or morally
     
  2. Disturb the composure of
    - faze, unnerve, unsettle

See also: debilitating, enervation

Type of: discomfit, discompose, disconcert, untune, upset, weaken