WordWeb Online

1. Making one feel out of place or alienated
   "the landscape was estranging"

1. Remove from customary environment or associations
   "years of boarding school estranged the child from her home"
    
2. Arouse hostility or indifference where there had formerly been love, affection, or friendliness
   "She estranged her friends when she became fanatically religious";
   - alienate, alien, disaffect

See also: disorienting

Type of: alter, change, modify, move out, remove, take out