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Adjective: heartsick  'haa(r)t,sik
  1. Full of sorrow
    "I hear from many heartsick people who are suffering from a great variety of losses";
    - brokenhearted, heartbroken
     
  2. Without or almost without hope
    "too heartsick to fight back";
    - despondent

See also: hopeless, sorrowful

Nearest

heartless
heartlessly
heartlessness
heart-lung machine
heartrending
heartrot
hearts
heartsease
heartseed
heart-shaped
heartsick
heartsickness
heartstrings
heartthrob
heart-to-heart
heartwarming
heart-whole
heartwood
hearty
heat
heat barrier