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Adjective: issueless  i-shoo-lus
  1. Having no issue
     
  2. [archaic] Having no progeny; childless

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Israeli Defense Force
Israeli monetary unit
Israelite
Israelites
Issachar
ISSN
issuable
issuance
issue
issue forth
issueless
issuer
issuing
issuing house
Issus
Istanbul
isthmian
Isthmian Games
isthmus
Isthmus of Corinth
Isthmus of Darien