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Adjective: malicious  mu'li-shus
  1. Marked by deep ill will; deliberately harmful
    "malicious gossip"; "took malicious pleasure in...watching me wince";
    - poisonous, venomous, vicious

See also: beady-eyed, bitchy, cattish, catty, despiteful, leering, malevolent, spiteful, venomed, vindictive, vixenish

Antonym: unmalicious

Encyclopedia: Malicious