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Adjective: stubborn  stú-bu(r)n
  1. Tenaciously unwilling or marked by tenacious unwillingness to yield
    - obstinate, unregenerate
     
  2. (medicine) not responding to treatment
    "a stubborn infection"; "stubborn rust stains";
    - refractory

See also: bloody-minded [Brit], bolshie [Brit], bolshy [Brit], bullet-headed, bullheaded, cantankerous, contrarious, cross-grained, determined, disobedient, dogged, dour, hardheaded, inflexible, intractable, mulish, persistent, pertinacious, pigheaded, stiff-necked, strong-minded, strong-willed, stroppy [Brit], sturdy, tenacious, uncompromising, unyielding

Antonym: docile

Encyclopedia: Stubborn