WordWeb Online

1. Nervous and unable to relax
   "In an overheated lobby filled with weak and twitchy light, Nathan shoulders open another door and steps into a little apartment";
   - antsy [N. Amer], fidgety, fretful, itchy
    
2. Tense, nervous, excited or irritable
   - on edge, keyed-up

Derived forms: twitchier, twitchiest

See also: anxious, nervous, queasy, tense, uneasy, unquiet

Encyclopedia: Twitchy