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Noun: vicissitude  vi'si-si,t(y)ood
  1. A variation in circumstances or fortune at different times in your life or in the development of something
    "the project was subject to the usual vicissitudes of exploratory research"
  2. Mutability in life or nature (especially successive alternation from one condition to another)

Derived forms: vicissitudes

Type of: fluctuation, mutability, mutableness, variation

Encyclopedia: Vicissitude