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Adjective: debilitating  du'bi-lu,tey-ting
  1. Impairing the strength and vitality
    "an acutely debilitating virus"
Verb: debilitate  di'bi-lu,teyt
  1. Make weak
    "Life in the camp debilitated him";
    - enfeeble, drain

See also: debilitative, draining, enervating, enfeebling, exhausting, weakening

Type of: weaken

Antonym: invigorating