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Noun: most significant bit
  1. (computing) the bit in a multiple-bit binary number with the largest value; this is usually the bit farthest to the left, or the bit transmitted first in a sequence. For example, in the binary number 1000, the MSB is 1, and in the binary number 0111, the MSB is 0
    - MSB

Derived forms: most significant bits

Encyclopedia: Most significant bit