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Adjective: fastidious  fa'stideeus
  1. Giving careful attention to detail; hard to please; excessively concerned with cleanliness
    "a fastidious and incisive intellect"; "fastidious about personal cleanliness"
     
  2. Having complicated nutritional requirements; especially growing only in special artificial cultures
    "fastidious microorganisms"
    - exacting

See also: choosey, choosy, dainty, fastidiously, fastidiousness, finical, finicky, fussy, meticulous, nice, old-maidish, old-womanish, overnice, particular, pernickety, persnickety, picky, prissy, refined, squeamish, tidy

Antonym: unfastidious