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Adjective: despairing  di'speh-ring
  1. Arising from or marked by despair or loss of hope
    "a despairing view of the world situation"; "the last despairing plea of the condemned criminal"
    - desperate
Verb: despair  di'spehr
  1. Abandon hope; give up hope; lose heart
    "Don't despair--help is on the way!"

See also: despairingly, desperate, desperation, hopeless

Antonym: hope

Encyclopedia: Despair Despair, Inc Despair, The torn heart

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Desmodus rotundus
Desmograthus
Desmond Tutu
desolate
desolately
desolateness
desolation
desorb
desorption
desoxyribonucleic acid
despair
despairingly
despatch
desperado
desperate
desperate criminal
desperate measure
desperate straits
desperately
desperateness